Pharmacokinetics and Tolerability of Oseltamivir Combined with Probenecid
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منابع مشابه
Pharmacokinetics and tolerability of oseltamivir combined with probenecid.
Oseltamivir is an inhibitor of influenza virus neuraminidase, which is approved for use for the treatment and prophylaxis of influenza A and B virus infections. In the event of an influenza pandemic, oseltamivir supplies may be limited; thus, alternative dosing strategies for oseltamivir prophylaxis should be explored. Healthy volunteers were randomized to a three-arm, open-label study and give...
متن کاملTitle: Effects of Probenecid on the Pharmacokinetics of the Neuraminidase Inhibitor Oseltamivir
Methods: Data from a total of 96 subjects, who received various dosages of oral and i.v. oseltamivir either in singleor repeated-dose regimens in four separate studies, and for whom rich PK data was available, were used for the development of the oseltamivir population PK model. Single dose data from 19 subjects in a fifth study, which included an OP arm and an OP + probenecid arm, were used to...
متن کاملEffect of Probenecid on Pharmacokinetics and Tolerability of Olmesartan in Healthy Chinese Volunteers☆
BACKGROUND Olmesartan is an angiotensin II receptor antagonist and is effective and well tolerated in the treatment of arterial hypertension. Probenecid is a well-established hypouricemic agent for the treatment of hyperuricemia and gout. OBJECTIVE The goal of this study was to examine the impact of coadministration of probenecid on the pharmacokinetic parameters and tolerability of olmesarta...
متن کاملThe pharmacokinetics and tolerability of oseltamivir suspension in patients on haemodialysis and continuous ambulatory peritoneal dialysis.
BACKGROUND Oseltamivir dose reduction is recommended for patients with end-stage renal disease (ESRD). However, dosing recommendations are not available for treatment or prophylaxis of influenza in these patients. This study assessed the pharmacokinetics and tolerability of oseltamivir in ESRD patients undergoing maintenance haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD...
متن کاملSafety, tolerability, and pharmacokinetics of intravenous oseltamivir: single- and multiple-dose phase I studies with healthy volunteers.
There is an unmet need for an intravenous (i.v.) neuraminidase inhibitor, particularly for patients with severe influenza who cannot take oral medication. Two phase I pharmacokinetic and safety studies of i.v. oseltamivir were carried out in healthy volunteers. The first was an open-label, randomized, four-period, two-sequence, single-dose trial of 100 mg, 200 mg, and 400 mg oseltamivir i.v. ov...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2008
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00047-08